Concept
musculoskeletal regenerative engineering
Parents
Children
441
Publications
28K
Citations
2.6K
Authors
805
Institutions
Biomimetic Anisotropic Scaffolds
2017 - 2021
During 2017–2021, the field consolidated a biomimetic paradigm where aligned, fibrous scaffolds and cell-laden hydrogel yarns guide collagen fiber alignment and cell orientation to mimic tendon and ligament anisotropy under combined mechanical and biochemical cues. Researchers increasingly employed niche- and extracellular matrix-inspired biomaterials to recreate stem cell microenvironments for rotator cuff and tendon regeneration, addressing hypocellularity with engineered matrices and decellularized ECM hydrogels. Advanced fabrication platforms such as electrospinning, braided and stacked fibrous architectures, and three-dimensional bioprinting enabled multi-scale, biomimetic architectures, while mechanobiology-driven strategies directed myogenesis and tendon differentiation, with mechanically triggered drug delivery to modulate repair dynamics.
• Fabrication of aligned, cell-laden hydrogel yarns and other fibrous scaffolds to mimic native tendon/ligament anisotropy, enabling guidance of collagen fiber alignment and cell orientation under mechanical and biochemical cues [1] [4] [6].
• Niche- and ECM-inspired biomaterials to recreate stem cell microenvironments for rotator cuff and tendon regeneration, addressing hypocellularity and limited intrinsic healing with engineered matrices and dECM-based hydrogels [2] [12] [13].
• Advanced fabrication platforms, including electrospinning, braided/stacked fibrous scaffolds and 3D bioprinting, enabling multi-scale, biomimetic architectures for musculoskeletal tissues (tendon, ligament, skeletal muscle) [6] [9] [14] [8] [15].
• Mechanobiology-driven tissue engineering where mechanical stimulation and mechanosensitive cues steer myogenesis, tendon differentiation and functional maturation, with mechanically triggered drug delivery to modulate repair processes [7] [17] [18] [20].